Which programs help adolescents struggling with social-emotional problems? That is the topic of a new research brief from Child Trends. The authors examine the effectiveness of 37 intervention programs designed to prevent or treat internalizing problems for adolescents ("internalizing problems" are defined as problems or disorders of emotion or mood caused by difficulties regulating negative emotion). Findings showed that programs are most effective when they build cognitive behavioral skills (such as redirecting negative or self-defeating thoughts), build behavioral coping skills for developing healthy responses to stress, and teach social skills for improving interpersonal relationships and self-efficacy. Therapeutic approaches, such as family therapy, group therapy, individual therapy, and treatment-focused, school-based approaches were also shown to be effective.